Resumo O objetivo do presente estudo é analisar os aspectos teóricos-empíricos do desenvolvimento com as Estações de Transbordo e Carga (ETC) e os desafios à saúde. O local do estudo foi o Distrito de Miritituba no município de Itaituba, Estado do Pará. Os dados primários foram obtidos nos anos de 2017 e 2018, com observação direta e aplicação de roteiro de entrevista aos representantes comunitários. Realizou-se análise do conteúdo na perspectiva descritiva, reflexiva e crítica, considerando os aspectos qualitativos do campo. Os resultados do estudo apontaram para as questões teórica e prática ao questionar sobre o tipo de desenvolvimento para a Amazônia. Concluiu-se que o planejamento para e na Amazônia necessita incluir as populações tradicionais da região, assim como apontar para modelos alternativos ao desenvolvimento, especialmente quando está em questão a saúde e a sobrevivência de culturas, ecossistemas e as várias formas de vida.

Abstract The purpose of the article is to discuss the functioning of the Genetic Heritage Management Council (CGen, acronym in Portuguese) from the enactment of Law No. 13,123 / 2015 until December 2019, to understand its role as coordinator of the benefit-sharing policy. CGen’s work context was presented and the theoretical framework of public policy coordination was discussed. The research was carried out based on the analysis of the minutes of the 24 meetings held by the Board, seeking to identify the frequency of full members, the participation of listeners, and the most discussed topics at the meetings. The CGen was found to be a leader in law enforcement, which seeks to use communication and standardization as mechanisms for its coordination. However, the low participation of beneficiaries of the policy and representatives of states and municipalities calls into question the effectiveness of the policy.

Resumen El objetivo de este estudio es analizar los aspectos teórico-empíricos del desarrollo de las Estaciones de Transbordo y Carga (ETC) y los desafíos para la salud. El sitio de estudio fue el Distrito de Miritituba en el municipio de Itaituba, Estado de Pará. Los datos primarios se obtuvieron en 2017 y 2018, con observación directa y aplicación de un guión de entrevista a representantes de la comunidad. El análisis de contenido se realizó en una perspectiva descriptiva, reflexiva y crítica, considerando los aspectos cualitativos del campo. Los resultados del estudio apuntaron a cuestiones teóricas y prácticas al preguntar sobre el tipo de desarrollo para la Amazonía. Se concluyó que la planificación para y en la Amazonía debe incluir a las poblaciones tradicionales de la región, así como señalar modelos alternativos de desarrollo, especialmente en lo que se refiere a la salud y supervivencia de culturas, ecosistemas y diversas formas de vida.

RESUMO No curso do desenvolvimento das relações de produção capitalista, o avanço tecnológico tem engendrado diferentes modos viver e produzir. Com as recentes transformações, pesquisas científicas no campo da Administração têm dado destaque sobre os modos como o consumidor tem se envolvido nas relações de produção, seja participando diretamente na coprodução dos produtos e serviços que consome, seja produzindo conteúdos criativos ou dados passíveis de serem aproveitados em prol da lucratividade de determinada empresa. Neste contexto, emergem as discussões sobre o prosumption, tratado como a união da atividade de consumo com a atividade de produção. A discussão sobre o prosumption se torna ainda mais complexa quando se leva em conta o recente movimento de expansão do comércio e da socialização mediados por plataformas digitais. Buscando ir além dos estudos predecessores que trataram do tema, analisamos o prosumption com base na teoria do valor, amparados na crítica da economia política marxiana. Expomos, assim, como as atividades do consumidor-produtor se integram à dinâmica da acumulação capitalista. Perscrutar o fenômeno prosumption nos permitiu apreender tanto o avanço do capital sobre a mercantilização das relações sociais, no qual atividades geradoras de forças naturais-sociais são transformadas em mercadorias e inseridas em processos de troca; quanto o maior potencial de exploração da classe trabalhadora, por meio da transferência de trabalhos necessários à produção e realização do valor ao consumidor.

In the development route of capitalist production relations, technological advancement has engendered different ways of living and producing. With the recent changes, scientific research in the Administration field has highlighted the ways in which the consumers have been involved in the production relations, either by participating directly in the co-production of the products and services they consume, or by producing creative content or data that can be used for the profitability of certain companies. In this context, discussions about prosumption have emerged, treated as the union of the consumption and production activities. The discussion about prosumption becomes even more complex when one takes into account the recent expansion movement of commerce and sociability mediated by digital platforms. Seeking to go beyond the predecessor studies that dealt with the topic, we analyzed the prosumption based on the theory of value, supported by the Marxian critique of political economy. Thus, we expose how consumer-producer activities are integrated with the dynamics of capitalist accumulation. Looking at the prosumption phenomenon allowed us to apprehend both: the advance of capital on the commodification of social relations, in which activities that generate natural-social forces are transformed into commodities and inserted in exchange processes; and the greater potential for exploitation of the working class, through the transfer of labor, necessary for production and realization of value, to the consumer.

En el curso del desarrollo de las relaciones de producción capitalistas, el avance tecnológico ha engendrado diferentes formas vivir y producir. Con los cambios recientes, la investigación científica en el campo de la Administración ha dado atención a las formas en las que el consumidor se ha involucrado en las relaciones de producción, ya sea participando directamente en la coproducción de los productos y servicios que consume, bien produciendo contenidos creativos o datos útiles para la rentabilidad de una determinada empresa. En este contexto, surgen discusiones sobre el prosumption, tratado como la unión de la actividad de consumo con la actividad de producción. La discusión sobre el prosumption se vuelve aún más compleja si se tiene en cuenta el reciente movimiento de expansión del comercio y la sociabilidad mediado por las plataformas digitales. Buscando ir más allá de los estudios predecesores que trataron el tema, analizamos el prosumption desde la teoría del valor, sustentada en la crítica de la economía política marxista. Así, exponemos cómo las actividades del consumidor-productor se integran con la dinámica de acumulación capitalista. La mirada al fenómeno prosumption nos permitió aprehender ambos: el avance del capital en la mercantilización de las relaciones sociales, en que las actividades generadoras de fuerzas naturales-sociales se transforman en mercancías y se insertan en los procesos de intercambio; y el mayor potencial de explotación de la clase trabajadora, a través de la transferencia de trabajo, necesario para la producción y realización del valor, al consumidor.

RESUMO Investigaram-se as alterações na composição orgânica do capital no setor bancário brasileiro, com foco nos processos de acumulação e centralização. Foram analisados relatórios econômico-financeiros de entidades reguladoras e de institutos de pesquisa. O exame demonstrou que o capital no setor rearticulou-se para diluir os limites à sua expansão, por meio, sobretudo, de alterações nos processos de trabalho, permitidas pela tecnologia.

ABSTRACT Changes in the organic composition of capital in the Brazilian banking sector were investigated, focusing on the accumulation and centralization process. Economic-financial reports from regulatory entities and research institutes were analyzed. The analysis shows that the capital in the sector has been rearticulated to dilute the limits to its expansion, mainly through changes in the work processes, allowed by technology.

ABSTRACT A molecular simulation algorithm was implemented to calculate chemical potentials of hard-core molecular systems at high densities. The method is based on the Widom particle insertion method and the step-function character of free energy variations. The algorithm was evaluated for hard-sphere mixtures at infinite dilution approximation by varying the solute/solvent diameter ratio, for systems with reduced densities from 0.1 to 0.8. The proposed methodology was verified by comparing simulations of trimers diluted in spheres and of single-component dimer systems with results from the literature. Then, the method was applied to mixtures of hard-spheres and dimers at several conditions regarding composition, reduced density, and bond-length/diameter ratio. The results were used to validate equations of state from the literature. The proposed approach was able to obtain accurate chemical potentials for different hard-core molecular mixtures. Lower uncertainties were obtained when comparing with traditional methods, especially at high densities.

ABSTRACT Pilosocereus pachycladus F. Ritter, Cactaceae, popularly known as "facheiro", is used as food and traditional medicine in Brazilian caatinga ecoregion. The plant is used to treat prostate inflammation and urinary infection. The present work reports the first secondary metabolites isolated from P. pachycladus. Therefore, the isolated compound 4-hydroxy-3,5-dimethoxy benzaldehyde (syringaldehyde) was evaluated as modulator of Staphylococcus aureus pump efflux-mediated antibiotic resistance. The isolation of compounds was performed using chromatographic techniques and the structural elucidation was carried out by spectroscopic methods. In order to evaluate syringaldehyde ability to modulate S. aureus antibiotic resistance, its minimum inhibitory concentrations (µg/ml) was first determinate, then, the tested antibiotics minimum inhibitory concentrations were determined in the presence of the syringaldehyde in a sub-inhibitory concentration. The chromatographic procedures led to isolation of twelve compounds from P. pachycladus including fatty acids, steroids, chlorophyll derivatives, phenolics and a lignan. The syringaldehyde did not show any antibacterial activity at 256 µg/ml against S. aureus. On the other hand the compound was able to reduce the antibiotic concentration (tetracycline, norfloxacin, ethidium bromide) required to inhibit the growth of drug-resistant bacteria, showing the ability of syringaldehyde of inhibiting the efflux pump on these bacteria.

From the aerial parts of Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) were isolated m-methoxy-p-hydroxy-benzaldehyde, o-hydroxy-benzoic acid, acacetin, quercetin, 7,4′-Di-O-methylisoscutellarein, genkwanin and tiliroside. These compounds were identified by data analyses of spectroscopic methods. Although acacetin and 7,4′-Di-O-methylisoscutellarein did not display relevant antibacterial activity (MIC = 256 µg/mL), they modulated the activity of antibiotics, i.e. in combination with antibiotics at 64 µg/mL (¼ MIC), a two-fold reduction in the MIC was observed for norfloxacin and ethidium bromide; regarding tetracycline and erythromycin a two-fold reduction in the MIC was observed only with 7,4′-Di-O-methylisoscutellarein.